The venom of a wasp native to Brazil could be used as a weapon to fight cancer, scientists believe. A toxin in the sting kills cancer cells without harming normal cells, lab studies suggest. The University of Brazil team say the experimental therapy latches to tumour cells and makes them leak vital molecules.
The work is at an early stage and more studies are needed to check the method will work safely in humans.
Polybia paulista is an aggressive social wasp endemic in south-east Brazil. Though its sting is largely seen as unwelcome, scientists increasingly believe it could be put to good use. It contains an important toxin called MP1 which the insect uses to attack prey or defend itself. And recent studies in mice suggest it may target and destroy cancer cells.
Prof Joao Ruggiero Netto and colleagues set out to discover how, by putting it under the microscope. They found MP1 interacts with fat molecules that are abnormally distributed on the surface of cancer cells, creating gaping holes that allow molecules crucial for cell function to leak out.In healthy cells, the same molecules are hidden on the inside. This means healthy tissue should avoid MP1’s attack, the scientists say in Biophysical Journal. Source: Wasp venom ‘a weapon against cancer’