Experimental anti-cholesterol drug shows promise

People taking an experimental drug called Repatha (evolocumab) for high cholesterol were half as likely to die or suffer a heart attack or stroke as those taking conventional statins, researchers said Sunday. The findings were based on 4,465 patients who were studied for one year after completing an earlier phase of the drug’s safety and efficacy testing. The results could offer an alternative to the estimated one in three Americans with high low-density lipoprotein (LDL) cholesterol who have been unable to manage their condition with diet, exercise and statin drugs currently on the market.

Patients were randomized to either receive evolocumab, made by the pharmaceutical company Amgen, injected under the skin in addition to standard care, or standard care alone, which meant taking the cholesterol-lowering statin drug recommended by their physician. Evolocumab works differently than traditional statins. It is a human monoclonal antibody that blocks a harmful protein in the liver, freeing the organ up to remove LDL cholesterol from the blood. This new class of drug is known as a PCSK9 inhibitor, and three different kinds, including evolocumab, are being studied in large clinical trials. Via Experimental anti-cholesterol drug shows promise.

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